The concomitant use of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors could end in a rise in methadone plasma concentrations, which could lead to probably deadly respiratory melancholy. Additionally, discontinuation of concomitantly employed cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers may also cause an increase in meth